Summary: BRCA1 promotes homologous recombination (HR) by activating DNA-end resection.By contrast, 53BP1 forms a barrier that inhibits DNA-end resection.Here, we show BODY WASH that BRCA1 promotes DNA-end resection by relieving the 53BP1-dependent barrier.We show that 53BP1 is phosphorylated by ATM in S/G2 phase, promoting RIF1 recruitment, which i

Neurodegenerative diseases are a group of disorders characterized by progressive degeneration or death of neurons.The complexity of clinical symptoms and irreversibility of disease progression significantly affects individual lives, leading to premature mortality.The prevalence of neurodegenerative diseases keeps increasing, yet the specific pathog

Rational bureaucratic models in various organizational contexts can no longer be implemented as originally designed because of the interaction of cultural locality, including in city-level police organizations.Services to the community in the District of Sukabumi cannot be implementedappropriately.It is because there are three problems, namely the

The main detector system at the Nuclotron-based Ion Collider fAcility (NICA) located in Dubna, Russia is the Multi-Purpose Detector (MPD).For better calibration reason, the MPD needs an additional trigger system for an off-beam calibration of MPD sub-detectors and for rejection (veto) of Telephone cosmic muons.The system should also be useful for p

Emel Aygören-Pürsün,1 Anette Bygum,2 Kathleen Beusterien,3 Emily Hautamaki,4 Zlatko Sisic,5 Henrik B Boysen,6 Teresa Caballero7 1Angioedema Centre, Department for Children and Adolescents, University Hospital Frankfurt, Goethe University, Frankfurt, Germany; 2Hereditary Angioedema Centre Denmark, Department of Dermatology and Allergy